吕志强

西北农林科技大学植保学院教授

吕志强，男，博士，西北农林科技大学植物保护学院昆虫学系教授，博士生导师。兼任中国昆虫学会生理生化专业委员会、昆虫发育与遗传专业委员会、国际交流与工作委员会及中国植保学会生物安全委员会委员，陕西省昆虫学会理事。

人物经历

1990.9-1994.7 西北农林科技大学农学系本科生

1994.9-1997.7 西北农林科技大学生物化学专业硕士研究生

2002.8-2007.5 美国俄克拉荷马州立大学昆虫学博士研究生

1997.7-1998.7 华中农业大学助教

1998.7-2000.10 重庆雨水集团生物医药研究所

2000.10-2002.8 国家生化工程中心（深圳）工程师

2007.7-2009.7 美国佐治亚大学博士后

2009.8- 西北农林科技大学植保学院教授

研究方向

1. 豌豆蚜免疫系统研究；

2. 寄生蜂-寄主昆虫免疫互作研究；

3.昆虫免疫与发育调控。

代表论文

Xu L, Ma L, Wang W, Li L, Lu Z. Phenoloxidases Are Required for the Pea Aphid Defense against Bacterial and Fungal Infection. Insect Molecular Biology. doi.org/10.1111/imb.12536 (in press)

Ma L, Zhou L, Lin J, Ji J, Wang Y, Jiang H, Shen X, Lu Z (2019) Manipulation of the silkworm immune system by a metalloprotease from the pathogenic bacterium Pseudomonas aeruginosa. Developmental & Comparative Immunology. 90:176-185.

Lin Z, Cheng Y, Wang R-J, Du J, Volovych O, Li J-C, Hu Y, Lu Z-Y, Lu Z, Zou Z (2019) A Metalloprotease Homolog Venom Protein From a Parasitoid Wasp Suppresses the Toll Pathway in Host Hemocytes. Frontiers in Immunology. 9:2301.

Chen K, Lu Z (2018) Immune responses to bacterial and fungal infections in the silkworm, Bombyx mori. Developmental & Comparative Immunology. 83:3-11.

Si M, Wang T, Pan J, Lin J, Chen C, Wei Y, Lu Z, Wei G, Shen X. (2017) Graded Response of the Multifunctional 2-Cysteine Peroxiredoxin, CgPrx, to Increasing Levels of Hydrogen Peroxide in Corynebacterium glutamicum. Antioxidants & Redox Signaling. 26, 1–14.

Wang R-J, Lin Z, Jiang H, Li J, Saha TT, Lu Z, Lu Z, Zou Z (2017) Comparative analysis of peptidoglycan recognition proteins in endoparasitoid wasp Microplitis mediator. Insect Science. 24:2–16.

Su L-D, Zhang Q-L, Lu Z (2017) Oxidation resistance 1 (OXR1) participates in silkworm defense against bacterial infection through the JNK pathway. Insect Science. 24:17–26.

Li J, Ma L, Lin Z, Zou Z, Lu Z (2016) Serpin-5 regulates prophenoloxidase activation and antimicrobial peptide pathways in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology. 73: 27-37

Chen K, Zhou L, Chen F, Peng Y, Lu Z (2016) Peptidoglycan recognition protein-S5 functions as a negative regulator of the antimicrobial peptide pathway in the silkworm, Bombyx mori. Developmental & Comparative Immunology. 61:126-135.

Otho SA, Chen K, Zhang Y, Wang P, Lu Z (2016) Silkworm ferritin 1 heavy chain homolog is involved in defense against bacterial infection through regulation of haemolymph iron homeostasis. Developmental & Comparative Immunology. 55:152-158.

Zhang Y, Lu Z (2015) Peroxiredoxin 1 protects the pea aphid Acyrthosiphon pisum from oxidative stress induced by Micrococcus luteus infection. Journal of Invertebrate Pathology. 127: 115–121.

Zhang L, Wang Y-W, Lu Z (2015) Midgut immune responses induced by bacterial infection in the silkworm, Bombyx mori. Journal of Zhejiang University Science B. 16: 875-882.

Ding W, Si M, Zhang W, Zhang Y, Chen C, Zhang L, Lu Z, Chen S, Shen X (2015) Functional characterization of a vanillin dehydrogenase in Corynebacterium glutamicum. Scientific Reports. 5: 8044.

Zhang L, Lu Z (2015) Expression, purification, and characterization of an atypical 2-Cys peroxiredoxin from the silkworm, Bombyx mori. Insect Molecular Biology. 24(2): 203–212

Chen K, Liu C, He Y, Jiang H, Lu Z (2014) A short-type peptidoglycan recognition protein from the silkworm: Expression, characterization and involvement in the prophenoloxidase activation pathway. Developmental & Comparative Immunology 45: 1-9.

Wang Y, Lu Z, Jiang H (2014) Manduca sexta proprophenoloxidase activating proteinase-3 (PAP3) stimulates melanization by activating proPAP3, proSPHs, and proPOs. Insect Biochemistry and Molecular Biology 50: 82-91.

Liu YB, Long MX, Yin YJ, Si MR, Zhang L, Lu ZQ, Wang Y, Shen XH (2013) Physiological roles of mycothiol in detoxification and tolerance to multiple poisonous chemicals in Corynebacterium glutamicum. Archives of Microbiology. Archives of Microbiology 195:419-429.

Shao Q, Yang B, Xu Q, Li X, Lu Z, et al. (2012) Hindgut Innate Immunity and Regulation of Fecal Microbiota through Melanization in Insects. Journal of Biological Chemistry 287: 14270-14279.

Zhao P, Lu Z, Strand MR, Jiang H (2011) Antiviral, anti-parasitic, and cytotoxic effects of 5,6-dihydroxyindole (DHI), a reactive compound generated by phenoloxidase during insect immune response. Insect Biochemistry and Molecular Biology 41: 645-652.

Lu Z, Beck MH, Strand MR (2010) Egf1.5 is a second phenoloxidase cascade inhibitor encoded by Microplitis demolitor bracovirus. Insect Biochemistry and Molecular Biology 40: 497-505.

Clark KD, Lu Z, Strand MR (2010) Regulation of melanization by glutathione in the moth Pseudoplusia includens. Insect Biochemistry and Molecular Biology 40: 460-467.

Lu Z, Beck MH, Wang Y, Jiang H, Strand MR (2008) The Viral Protein Egf1.0 Is a Dual Activity Inhibitor of Prophenoloxidase-activating Proteinases 1 and 3 from Manduca sexta. Journal of Biological Chemistry 283: 21325-21333.

Tribolium Genome Sequencing Consortium: Immunity: Zhen Zou, Jay Evans, Zhiqiang Lu, Picheng Zhao, Niranji Sumathipala, Boran Altincicek, Andreas Vilcinskas, Michael Williams, Dan Hultmark, Charles Hetru, Haobo Jiang (2008) The genome of the model beetle and pest Tribolium castaneum. Nature, 452(7190): 949-955.

Lu Z, Jiang H (2008) Expression of Manduca sexta serine proteinase homolog precursors in insect cells and their proteolytic activation. Insect Biochemistry and Molecular Biology 38: 89-98.

Huang R, Lu Z, Dai H, Vander Velde D, Prakash O, Jiang H (2007) The Solution Structure of Clip Domains from Manduca sexta Prophenoloxidase Activating Proteinase-2. Biochemistry 46: 11431-11439.

Zou Z, Evans J, Lu Z, Zhao P, Williams M, Sumathipala N, Hetru C, Hultmark D, Jiang H (2007) Comparative genomic analysis of the Tribolium immune system. Genome Biology 8: R177.

Lu Z, Jiang H (2007) Regulation of phenoloxidase activity by high- and low-molecular-weight inhibitors from the larval hemolymph of Manduca sexta. Insect Biochemistry and Molecular Biology 37: 478-485.

Zhang G, Lu Z-Q, Jiang H, Asgari S (2004) Negative regulation of prophenoloxidase (proPO) activation by a clip-domain serine proteinase homolog (SPH) from endoparasitoid venom. Insect Biochemistry and Molecular Biology 34: 477-483.

Jiang H, Ma C, Lu Z, Kanost MR. (2004) β-1,3-Glucan recognition protein-2 (βGRP-2) from Manduca sexta: an acute-phase protein that binds β-1,3-glucan and lipoteichoic acid to aggregate fungi and bacteria and stimulate prophenoloxidase activation. Insect Biochemistry and Molecular Biology 34: 89-100.

张永栋, 李君兰, 陈金红, 马力, 陈康康, 吕志强 (2017) Identification and characterization of peroxiredoxin 2 involved in the antioxidative response induced by bacterial infection in the pea aphid， Acyrthosiphon pisum (Hemiptera： Aphididae). 昆虫学报. 60(3)：254-263

陈金红, 徐露, 马力, 吕志强 (2017) 过氧化氢酶在豌豆蚜抵御藤黄微球菌和大肠杆菌感染引起的氧化胁迫中的作用. 昆虫学报.60(10)：1178-1186

张巧伶, 苏立德, 吕志强 (2015) 细菌感染对家蚕DNA甲基化与组蛋白乙酰化相关基因表达的影响. 昆虫学报. 58 (9): 941-949

陈康康，吕志强 (2014) 昆虫肽聚糖识别蛋白研究进展. 昆虫学报. 57(8)：969-978.

王鹏，王维，吕志强 (2014) 家蚕半乳糖凝集素BmGalectin-4的表达、纯化及性质分析. 昆虫学报. 57(7): 806-814.

朱艳菊，吕志强 (2013) Identification of differentially expressed genes in the larval midgut of the silkworm (Bombyx mori) after bacterial infection. 昆虫学报. 56(5): 505-511.

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