王明齐

江苏大学药学院副教授

王明齐，男，1987年5月生，博士，江苏大学药学院副教授，硕士生导师。

个人经历

教育经历：

2005.09-2009.06 淮阴师范学院，化学专业，获学士学位

2009.09-2014.07 四川大学，有机化学专业，获博士学位

工作经历：

2012.06-2013.01冈山大学（Okayama University），日本，国际交流合作

2014.07-至今江苏大学药学院讲师

2016.12-至今江苏大学，博士后

研究方向

1、核酸药物化学和核酸化学生物学

2、自组装荧光纳米探针

3、化学生物传感

学术成果

科研项目（项目负责人）：

1、端粒G4-DNA为靶点的喹啉类衍生物结构修饰及机理研究，中国博士后科学基金，主持

2、端粒DNA识别分子的核酸调控及相关信号转导干预研究，江苏高等学校自然科学研究面上项目，主持

3、基于深红/近红外两亲性BODIPY荧光分子自组装：分子设计、G-四链体DNA识别与生物应用，江苏省青年科学基金，主持

4、 G-四链体DNA荧光探针分子的设计合成及其抗肿瘤活性研究，江苏大学高级人才启动，主持，已结题

代表性论著（第一作者和通讯作者论文）：

[1] Wang Ming-Qi*, Xu Jing, Zhang Lan, Liao Yue, Wei Heng, Yin Ying-Ying, Liu Qiang*, Zhang Lan. Tuning the selectivity of N-alkylated styrylquinolinium dyes for sensing of G-quadruplex DNA. Bioorganic & Medicinal Chemistry, 2019

[2] Wang Ming-Qi*, Ren Gui-Ying, Zhao Shuang, Lian Guang-Chang, Chen Ting-Ting, Ci Yang, Li Hong-Yao. Development of a carbazole-based ﬂuorescence probe for G-quadruplex DNA: The importance of side-group effect on binding speciﬁcity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018

[3] Zhang Feng, Li Gan, Lv Fang-Lei, Jiang Guang-Bin, Wang Han-Xiang, Wang Ming-Qi*, Li Shuo*. A far-red ﬂuorescent probe for selective G-quadruplex DNA targeting. Tetrahedron Letters 2018

[4] Wang Ming-Qi*, Liu Xiao-Ning, Guo Zhong-Jian*, Feng chunlai*, Rui mengjie, Synthesis of quinolinium-based probes and studies of their effects for selective G-quadruplex DNA targeting, New Journal of Chemistry, 2018

[5] Wang Ming-Qi*, Wu Yuan, Wang Zi-Yu, Chen Qiu-Yun*, Xiao Fu-Yan, Jiang Yu-Chi, Sang Amy, G-quadruplex DNA ﬂuorescence sensing by a bis-amine-substituted styrylquinolinium dye, Dyes and Pigments, 2017

[6] Wang Ming-Qi*, Wang Zi-Yu, Yang Yi-Fan, Ren Gui-Ying, Liu Xiao-Ning, Li Shuo*, Wei Jian-Wei, Zhang Lan, Development of a light-up ﬂuorescent probe for HRAS G-quadruplex DNA. Tetrahedron Letters, 2017

[7]Wang Ming-Qi*, Liu Shuo, Tang Cai-Ping, Raza Aun, Li Shuo*, Gao Lie-Xiong, Sun Jing*, Guo Song-Ping, Flexible amine-functionalized triphenylamine derivative as a ﬂuorescent “light-up” probe for G-quadruplex DNA, Dyes and Pigments, 2017

[8] Wang Ming-Qi, Gao Lie-Xiong, Yang Yi-Fan, Xiong Xian-Ning, Zheng Zhao-Yi, Li Shuo*, Wu Yuan, Ma Lu-Lu, A triphenylamine derivative as a naked-eye and light-up fluorescent probe for G-quadruplex DNA, Tetrahedron Letters, 2016

[9] Wang Ming-Qi*, Dong Juan, Zhang Huafan, Tang Zhuo*.Characterization of deoxyribozymes with site-speciﬁc oxidative cleavage activity against DNA obtained by in vitro selection, Organic & Biomolecular Chemistry, 2016

[10] Wang Ming-Qi*, Zhu Wen-Xiang, Song Zhuan-Zhuan, Li Shuo*, Zhang Yong-Zhao, A triphenylamine-based colorimetric and ﬂuorescent probe with donor–bridge–acceptor structure for detection of G-quadruplex DNA, Bioorganic & Medicinal Chemistry Letters, 2015

[11] Wang Ming-Qi, Zhang Hua-Fan, Zhang Wei, Zhao Yong-yun, Yasmeen Afshan, Zhou Li, Yu Xiao-Qi*, Tang Zhuo*, In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity, Nucleic Acids Research, 2014

[12] Wang Ming-Qi, Li Kun*, Xu Hao-Ran, Yu Xiao-Qi*, Imidazolium-based 1,1’-bi-2-naphthol fluorescent probe for ratiometric and selective detection of DNA in water, Analytical Methods, 2013

[13] Wang Ming-Qi, Li Kun*, Hou Li-Ting, Wu Ming-Yu, Huang Zeng, Yu Xiao-Qi*, BINOL-Based fluorescent sensor for recognition of Cu(II) and sulfide anion in water, Journal of Organic Chemistry, 2012

[14] Wang Ming-Qi, Zhang Ji, Zhang Yu, Zhang Da-Wei, Liu Qiang, Liu Jun-Liang, Lin Hong-Hui*, Yu Xiao-Qi*, Metal-free cleavage efficiency toward DNA by a novel PNA analog-bridged macrocyclic polyamine, Bioorganic & Medicinal Chemistry Letters, 2011

[15] Wang Ming-Qi, Liu Jun-Liang, Wang Jing-Yi, Zhang Da-Wei, Zhang Ji, Streckenbach Frank, Tang Zhuo*, Lin Hong-Hui*, Liu Yan, Zhao Yu-Fen, Yu Xiao-Qi*, Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate, Chemical Communications, 2011

授权发明专利：

[1] 一种具有电荷转移特性的荧光探针及其制备方法和用途。

[2] 一种α-Fe2O3磁性纳米棒的制备方法。

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